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Hematology & Oncology Clinical Calculators

Evidence-based hematology and oncology calculators for heparin-induced thrombocytopenia (4Ts HIT Score), thrombotic microangiopathy (PLASMIC Score), disseminated intravascular coagulation (ISTH DIC Score), bleeding severity (WHO Bleeding Scale), and lymphoma prognosis (IPI NHL).

Why This Matters

Hematologic and oncologic emergencies require rapid, accurate risk stratification to guide life-saving interventions. Heparin-induced thrombocytopenia (HIT) occurs in 0.5-5% of heparin-exposed patients and carries a 30-50% thrombotic risk if not recognized early. The 4Ts Score enables rapid pretest probability assessment, reducing unnecessary testing while ensuring timely diagnosis. Thrombotic thrombocytopenic purpura (TTP) has >90% mortality if untreated, but the PLASMIC Score helps identify patients who need urgent plasma exchange. Disseminated intravascular coagulation (DIC) affects 30-50% of patients with sepsis and carries substantial mortality — the ISTH DIC Score provides objective diagnostic criteria. The WHO Bleeding Scale is the standard for bleeding severity classification in oncology patients, guiding platelet transfusion decisions worldwide. The International Prognostic Index (IPI) is an essential tool for risk stratification and treatment planning in aggressive non-Hodgkin lymphoma, with 5-year survival ranging from 26% (high risk) to 73% (low risk). These validated tools are endorsed by ASH, ISTH, WHO, and international lymphoma guidelines.

When to Use

Use 4Ts HIT Score for any patient on heparin (UFH or LMWH) who develops thrombocytopenia, thrombosis, or skin lesions at injection sites. Use PLASMIC Score for patients presenting with thrombotic microangiopathy (microangiopathic hemolytic anemia + thrombocytopenia) to assess probability of TTP. Use ISTH DIC Score for patients with underlying conditions associated with DIC (sepsis, trauma, malignancy, obstetrical complications) who develop laboratory abnormalities suggesting consumptive coagulopathy. Use WHO Bleeding Scale for standardized assessment of bleeding severity in oncology patients, chemotherapy-induced thrombocytopenia, and hematopoietic stem cell transplant recipients. Use IPI NHL at diagnosis of aggressive non-Hodgkin lymphoma (particularly DLBCL) for prognostic stratification and treatment planning.

Our hematology and oncology calculators are developed in accordance with international guidelines including the American Society of Hematology (ASH) guidelines for HIT and TTP management, the ISTH Scientific and Standardisation Committee DIC scoring recommendations, the WHO Handbook for Reporting Results of Cancer Treatment, and the International Non-Hodgkin's Lymphoma Prognostic Factors Project. Each tool includes original validation data, clinically relevant cutoff values, and guideline-based management recommendations.

Available Hematology & Oncology Calculators

Clinical Guidelines

  • ASH Guidelines for Management of Heparin-Induced Thrombocytopenia (2023)
  • ASH Guidelines for Management of Thrombotic Thrombocytopenic Purpura (2024)
  • ISTH DIC Scoring Recommendations (2001, Updated 2023)
  • WHO Handbook for Reporting Results of Cancer Treatment (1979, CTCAE v5.0 2017)
  • International Prognostic Index for Aggressive NHL — Shipp et al. NEJM 1993
Enhance your hematology-oncology practice with Tabeeb+ clinic management software. Document HIT probability scores, DIC scores, bleeding grades, and IPI scores in patient records with automated calculation and longitudinal tracking of treatment response and outcomes.

Frequently Asked Questions

The 4Ts HIT Score is the most widely validated and commonly used clinical prediction rule for HIT, recommended by ASH and CHEST guidelines. It has excellent negative predictive value (>99% for score 0-3) making it an ideal rule-out tool. The HEP Score was developed specifically for post-cardiac surgery patients where the 4Ts has lower specificity. In general medical and surgical patients, the 4Ts Score is preferred due to its simplicity and extensive validation.
The WHO Bleeding Scale is a simple 5-grade (0-4) global assessment of bleeding severity originally designed for cancer treatment reporting. CTCAE v5.0 provides organ-specific bleeding grading (e.g., CNS hemorrhage, GI hemorrhage, pulmonary hemorrhage each graded 1-5 separately) with greater granularity. In clinical practice, the WHO scale is preferred for rapid bedside assessment, while CTCAE is used for comprehensive adverse event reporting in clinical trials. Both systems classify Grade 3 as requiring transfusion and Grade 4 as life-threatening.
The International Prognostic Index (IPI) uses 5 risk factors (age >60, elevated LDH, ECOG ≥2, stage III/IV, extranodal involvement >1 site) to classify aggressive NHL patients into 4 risk groups with 5-year survival from 73% (low risk, score 0-1) to 26% (high risk, score 4-5). Low-risk patients receive standard R-CHOP with excellent outcomes. High-risk patients may benefit from intensified regimens (dose-adjusted EPOCH-R) or clinical trial enrollment. The IPI is recommended by NCCN and ESMO guidelines for all newly diagnosed DLBCL patients.

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Medical Disclaimer: This calculator is intended for use by healthcare professionals for educational and clinical decision support purposes only. It is not a substitute for professional clinical judgment.
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